#STEM CELL TREATMENT FOR OSTEOARTHRITIS TRIAL#

Published in Stem Cells Translational Medicine in 2017, the animal studies yielded promising results. Researchers delivered culture-expanded human AMSCs, grown in human platelet-lysate, via intra-articular injections into normal healthy rabbit knees and knees at risk for the development of osteoarthritis after bilateral medial anterior hemimeniscectomy.

#STEM CELL TREATMENT FOR OSTEOARTHRITIS TRIAL#

In preparation for a phase I clinical trial using AMSCs to treat patients with osteoarthritis, Mayo Clinic researchers conducted animal studies using rabbits that demonstrated a favorable safety profile for AMSCs within the joint space. Stem cells harvested from fat also grow quickly and are quite resilient when grown in the laboratory. Stem cells exist throughout the body, but they are particularly prevalent in bone marrow and in fat. AMSCs have received increasing attention as a possible therapeutic agent for OA of the knee. To address this challenge, researchers across the globe are searching for nonsurgical interventions that will alter the course of this disease or prevent it.Дerived from the stromal vascular fraction of adipose tissue, adipose-derived mesenchymal stem cells (AMSCs) are immature mesenchymal cells with stem cell-like properties. The only complete cure is a total knee arthroplasty.

Although effective at relieving acute pain symptoms, currently available nonsurgical treatments are associated with significant potential for adverse side effects, and they do not slow or reverse disease progression.

Stem cell treatment for osteoarthritis